讲座题目：Magnesium Metals with Polymer Composite Coatings for Orthopedic Applications

聚合物基复合涂层包裹的镁金属及其在骨修复领域的应用

主讲嘉宾：魏涛 教授

讲座时间： 2019年12月20日 10:00-11:30（周五）

讲座地点： 化工楼A316

报告摘要：Magnesium (Mg) and its alloys have been intensively explored as the next-generation of metallic bone substitutes in the past decades, but their rapid corrosion rate in physiological environments is still a great hindrance for further therapeutic applications. In this talk, I will introduce our recent work in designing the biodegradable poly (L-lactic acid) (PLLA) coatings on pure Mg substrates (99.99 wt.%) with tunable surface morphologies through dip-coating in combination with mixed non-solvent induced phase separation (Dip-coating-mNIPS) method to regulate the corrosion behavior and biocompatibility. By using the mixtures of solvents, we obtained PLLA coatings with different pore sizes and morphologies. We further developed an organic-inorganic composite coating consisting of PLLA and water-soluble Mg salt particles served as a protective layer on the surface of a pure Mg substrate. Compared to the pure PLLA coating, the implementation of the Mg salt coating could allow for quick initial release of Mg²⁺and impeded degradation of the Mg substrate simultaneously. In particular, we demonstrated that the composite-coated sample favored cellular adhesion and attachment, cell spreading, and cellular proliferation. These encouragingin vitrodata provide significant evidence of the potential practical value of this PLLA-based composite coating on Mg substrates for numerous orthopedic applications.

报告简介：镁及镁合金是下一代骨修复及替代材料的研究热点，但是其在体液环境下的快速降解阻碍了其在临床的进一步应用。在该报告中，报告人将系统介绍通过浸涂方法制备的表面形貌可控的生物可降解聚乳酸涂层。将该涂层涂覆于纯度大于99.99%的金属镁表面，通过非溶剂调节分相程度和分相速度，得到具有不同孔径和形貌的聚合物涂层，这可以调控腐蚀速率和生物相容性。进一步地，我们制备了聚乳酸和镁盐构成的有机-无机复合涂层。镁盐颗粒可以作为纯镁基底的保护膜，这一方面可以提供释放初期的镁离子，另一方面可以降低镁基底的腐蚀速率。复合涂层提供了更好的细胞黏附、细胞铺展和细胞增殖。因此，这些体外数据为聚乳酸基的聚合物复合涂层在镁基骨修复领域的实际应用提供了重要的基础。

报告人简介：魏涛，博士，香港中文大学化学系教授，理学院助理院长，英国皇家化学学会会士。他在香港中文大学师从吴奇院士，研究高分子激光光散射和高分子溶液理论，于2003年获得博士学位；随后赴德国巴斯夫路德维希总部开展了两年的博士后工作，主要研究领域为胶体与表面化学。之后赴明尼苏达大学Timothy P. Lodge课题组开展了短期研究。他于2006年在香港中文大学任职，于2017年升任正教授。他目前的研究领域主要为胶体、表面化学、高分子和软物质等。